Figure 3

A step by step protocol applied on day 4 post infection for predicting CM. Item+P₄ score should be used to estimate the probability of CM development on any time between days 5 - 10 post infection. Item⁷² and Item+P⁷² should be used to estimate the probability of CM development on day 7 post infection (72 hours after day 4 post infection). SHIRPA tests and its respective weights compounding each score are shown in the third line. Values obtained for each SHIRPA test should be multiplied by its respective weight and summed up to get a final score. A decision rule based on a specific final value for each score is shown. A final score above or equal (≥) this value is considered positive and is associated with a high probability of cerebral malaria (CM) development. On the other hand, a final score below this value (<) is considered negative and is associated with a low probability of CM. RIJ = Rearing in Jar; GIJ = Grooming in Jar; FP = Faecal Pellets; SA = Spontaneous Activity; RRa = Respiration Rate; TE = Tail Elevation; TC = Trunk Curl; LG = Limb Grasping; VP = Visual Placing; GS = Grip Strength; BT = Body Tone; PR = Pinna Reflex; CR = Corneal Reflex; LT = Limb Tone; RR = Righting Reflex; CRR = Contact Righting Reflex; A = Aggression; P = Parasitemia.