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Table 3 Protective effect of polymorphisms in the genes of IL12A and its receptor, IL12RB1, against severe malaria anaemia

From: Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

 

Severe malaria anaemia episodes crude incidence/1000 person-months

Adjusted risk ratio (95% CI)a

IL12 A-rs2243140b

TT

TC

CC

CC vs TT

TC vs TT

P

 

12.2

7.7

0

0.28 (0.10-0.79)

0.52 (0.31-0.89)

.006

IL12RB1-rs429774c

TT

TC

CC

CC vs (TT+TC)

 

P

 

12.2

11.2

2.8

0.18 (0.05-0.69)

 

.00005

  1. NOTE.
  2. a Adjusted by sickle cell type and treatment with anti-malarial drugs.
  3. b An additive genetic model used for IL12A-rs2243140, which treats the marker as a continuous variable and is extrapolated based on Poisson model.
  4. c A dominant model used for the second marker, IL12RB1-rs429774.