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Table 5 Evolution of biological parameters with respect to AL, ASAQ and DHAP

From: Randomized non-inferiority and safety trial of dihydroartemisin-piperaquine and artesunate-amodiaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroonian children

Parameter

AL

 

ASAQ

 

DHAP

  
 

DO

D7

D0-D7

P*

DO

D7

D0-D7

P*

DO

D7

D0-D7

P*

P+

Hb (g/dl)

10.2

9.56

0.46

0.003

10.4

9.92

0.48

0.367

9.92

9.37

0.55

0.001

0.988

[SD]

[2.2]

[1.93]

[1.67]

[6.90]

[5.63]

[8.55]

[2.15]

[1.82]

[1.79]

ALAT (IU/l)

28.07

22.01

6.05

0.114

23.59

29.61

−0.61

0.134

25.75

35.33

−9.58

0.288

0.355

[SD]

[40.25]

[16.16]

[42.19]

[19.30]

[0.47]

[63.57]

[2.62]

[7.3]

[14.67]

CREA (mg/l)

0.76

1.07

−0.31

0.476

0.65

0.68

−0.03

0.565

0.71

1.1

−0.39

0.171

0.531

[SD]

[1.04]

[4.74]

[4.84]

[0.03]

[0.06]

[0.88]

[0.72]

[4.46]

[4.52]

  1. P* = paired t test, P== F test from anova (comparing difference across three drugs); Hb = haemoglobin level.
  2. [SD] = Standard deviation, ALAT = alanine aminotransferase, CREA = Creatinine level.