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Table 3 KCS sensitivity by assay for values ≥ LLD

From: Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies

Diagnosis by method (blood volume)*

D6.5

D7.0

D7.5

UW large volume qRT-PCR (0.5 mL)

37.0%

100.0%

100.0%

Oxford qPCR (0.5 mL)

25.9%

96.3%

100.0%

UW standard qRT-PCR (0.05 mL)

3.7%

70.4%

88.9%

UW DBS qRT-PCR (0.05 mL)

0.0%

50.0%

84.6%

 

n = 27 (n = 26 DBS)

  1. *KCS malaria diagnosis definition by D21 as the gold standard comparator.
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Malaria Journal

ISSN: 1475-2875

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