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Table 3 Genotypic and allelic frequencies of single nucleotide polymorphisms in malaria (+) and malaria (−) groups

From: IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon

Studied polymorphisms   Malaria (+) (n = 73) Malaria (−) (n = 194) OR (95% CI) * P value
IFNG + 874 T/A      
Genotypes A/A 38 (52%) 101 (52.1%) 1.00 0.92
  A/T 30 (41.1%) 77 (39.7%) 0.97 (0.55-1.70)
  T/T 5 (6.8%) 16 (8.2%) 1.20 (0.41-3.51)
Alleles A 106 (73%) 279 (72%) 0.16 (0.68 - 1.58) 0.87
  T 40 (27%) 109 (28%)
NOS2A-952G/C      
Genotypes G/G 70 (95.9%) 183 (94.3%) 1.00 0.6
  G/C 3 (4.1%) 11 (5.7%) 1.40 (0.38-5.18)
  C/C - - -
Alleles G 143 (98%) 377 (97%) 1.39 (0.38 - 5.05) 0.6
  C 3 (2%) 11 (3%)
IL10A-1082G/A      
Genotypes A/A 3 (4.1%) 40 (20.6%) 1.00 0.0009
  G/A 64 (87.7%) 135 (69.6%) 0.16 (0.05-0.53)
  G/G 6 (8.2%) 19 (9.8%) 0.24 (0.05-1.05)
Alleles A 70 (48%) 215 (62%) 0.74 (0.50 - 1.08) 0.12
  G 76 (52%) 173 (45%)
IL10A-592A/C and IL10A-819 T/C      
Genotypes C/C 13 (17.8%) 70 (36.1%) 1.00 0.0002
  A/C; T/C 36 (49.3%) 100 (51.1%) 0.52 (0.26-1.04)
  A/A; T/T 24 (32.9%) 24 (12.4%) 0.19 (0.08-0.42)
Alleles C 62 (42%) 240 (62%) 0.45 (0.30 - 0.67) 0.0001
  A/T 84 (58%) 148 (38%)
  1. IFNG + 874 T/A, NOS2A-954G/C, IL10A-1082G/A, IL10A-592A/C and IL10A-819 T/C polymorphisms: Alleles, n (%); Genotypes n (%); OR (95% CI), calculating odds ratios with confidence interval (CI) of 95%; *Analysis by χ2 test using the Fisher model codominance.