Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

Table 1 Cross-correlation (Pearson’s r) between growth inhibition to anti-malarial drugs where n is the number of paired IC ₅₀ s analysed

		Chloroquine	Naphthoquine	Piperaquine	Pyronaridine	Lumefantrine	Dihydro-artemisinin	Artesunate
Naphthoquine	r	0.35^*
	P	0.020
	n	45
Piperaquine	r	0.44^**	0.55^**
	P	0.002	<0.001
	n	45	44
Pyronaridine	r	0.19	0.49^**	0.31^*
	P	0.23	0.001	0.042
	n	43	44	43
Lumefantrine	r	−0.08	0.21	−0.03	0.13
	P	0.62	0.18	0.86	0.40
	n	42	42	42	42
Dihydro-artemisinin	r	0.27	0.20	0.33^*	0.47^**	0.11
	P	0.065	0.18	0.026	0.001	0.48
	n	48	47	47	45	44
Artesunate	r	0.28	0.38^**	0.27	0.45^**	0.24	0.66^**
	P	0.060	0.009	0.067	0.002	0.12	<0.001
	n	47	46	47	45	44	49
Artemether	r	0.24	0.37^*	0.29^*	0.29	0.04	0.49^**	0.64^**
	P	0.11	0.012	0.048	0.053	0.78	<0.001	<0.001
	n	46	46	46	45	44	48	48

The data were log-transformed before analysis. The symbols * and ** indicate P < 0.05 and P < 0.01, respectively.

ISSN: 1475-2875