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Table 1 Cross-correlation (Pearson’s r) between growth inhibition to anti-malarial drugs where n is the number of paired IC 50 s analysed

From: Temporal changes in Plasmodium falciparum anti-malarial drug sensitivity in vitro and resistance-associated genetic mutations in isolates from Papua New Guinea

   Chloroquine Naphthoquine Piperaquine Pyronaridine Lumefantrine Dihydro-artemisinin Artesunate
Naphthoquine r 0.35*       
P 0.020       
n 45       
Piperaquine r 0.44** 0.55**      
P 0.002 <0.001      
n 45 44      
Pyronaridine r 0.19 0.49** 0.31*     
P 0.23 0.001 0.042     
n 43 44 43     
Lumefantrine r −0.08 0.21 −0.03 0.13    
P 0.62 0.18 0.86 0.40    
n 42 42 42 42    
Dihydro-artemisinin r 0.27 0.20 0.33* 0.47** 0.11   
P 0.065 0.18 0.026 0.001 0.48   
n 48 47 47 45 44   
Artesunate r 0.28 0.38** 0.27 0.45** 0.24 0.66**  
P 0.060 0.009 0.067 0.002 0.12 <0.001  
n 47 46 47 45 44 49  
Artemether r 0.24 0.37* 0.29* 0.29 0.04 0.49** 0.64**
P 0.11 0.012 0.048 0.053 0.78 <0.001 <0.001
n 46 46 46 45 44 48 48
  1. The data were log-transformed before analysis. The symbols * and ** indicate P < 0.05 and P < 0.01, respectively.