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Table 1 Interaction between artemisinin and various fluoroquinolones analogs (compounds 10, 12 and 18) against Plasmodium falciparum (3D7 strain) at six different preparations

From: In vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against Plasmodium falciparum; their antiplasmodial action in rodent malaria model

Combination solution (Ratio A:B)

Drug A (Artemisinin) Mean FIC 50   ± SE a

Drug B (Compound-10) Mean FIC 50   ± SE a

ÎŁ FICs, interaction b

1 (5:0)

1.02 ± 0.04

0

 

2 (4:1)

0.61 ± 0.01

0.15 ± 0.02

0.76 SYN

3 (3:2)

0.58 ± 0.03

0.22 ± 0.02

0.80 SYN

4 (2:3)

0.48 ± 0.02

0.53 ± 0.03

1.01 ADD

5 (1:4)

0.17 ± 0.03

0.41 ± 0.03

0.58 SYN

6 (0:5)

0

0.93 ± 0.04

 

Combination solution (Ratio A:B)

Drug A (Artemisinin) Mean FIC 50   ± SE a

Drug B (Compound-12) Mean FIC 50   ± SE a

ÎŁ FICs, interaction b

1 (5:0)

1.0 ± 0.02

0

 

2 (4:1)

0.63 ± 0.03

0.15 ± 0.003

0.78 SYN

3 (3:2)

0.60 ± 0.03

0.23 ± 0.02

0.83 SYN

4 (2:3)

0.50 ± 0.02

0.77 ± 0.03

1.27 ADD

5 (1:4)

0.25 ± 0.004

0.32 ± 0.01

0.56 SYN

6 (0:5)

0

1.11 ± 0.08

 

Combination solution (Ratio A:B)

Drug A (Artemisinin) Mean FIC 50   ± SE a

Drug B (Compound 18) Mean FIC 50   ± SE a

ÎŁ FICs, interaction b

1 (5:0)

0.97 ± 0.07

0

 

2 ( 4:1)

0.58 ± 0.02

0.16 ± 0.01

0.73 SYN

3 (3:2)

0.55 ± 0.03

0.47 ± 0.03

1.02 ADD

4(2:3)

0.49 ± 0.04

0.66 ± 0.03

1.15 ADD

5 (1:4)

0.22 ± 0.01

0.33 ± 0.02

0.55 SYN

6 (0:5)

0

0.97 ± 0.08

 

Combination solution (Ratio A:B)

Drug A (Artemisinin) Mean FIC 50   ± SE a

Drug B (Norfloxacin) Mean FIC 50   ± SE a

ÎŁ FICs, interaction b

1 (5:0)

1.13 ± 0.06

0

 

2 (4:1)

0.91 ± 0.03

0.45 ± 0.02

1.36 ADD

3 (3:2)

0.29 ± 0.02

0.52 ± 0.04

0.81 SYN

4 (2:3)

0.66 ± 0.02

0.87 ± 0.03

1.53 ADD

5 (1:4)

0.14 ± 0.01

0.60 ± 0.02

0.74 SYN

6 (0:5)

0

0.98 ± 0.04

 
  1. aStandard error (n = 3); bADD, additive; SYN, synergistic.