Figure 8

A schematic diagram of MSP1 and its interactions in Plasmodium and human. A A schematic Venn diagram for identification of important proteins. PFI1475w (MSP1) is one of the IIPs identified using this protocol and presented here as an example. In the panel B intra Plasmodium stage specific interactions of MSP1 are represented as schematic circular networks in six different boxes where each box represent a particular life cycle stage marked at the bottom right corner of the box. Unique stage specific interactors are marked separately in the boxes. In panel C human partners of these MSP1 interacting proteins are presented. The numbers on the proteins corresponds to the name mentioned at Additional file 23: Table S8. Pathways of the Plasmodium interactors (from panel B) and human proteins (from panel C) are represented as two bar charts (panel D and E, respectively). The proteins are represented here as small circles and their corresponding stages are represented as a circular colour pattern at the circumference of the circle. The stage(s) where the particular protein is expressed is filled with corresponding colour and other stage(s) are left blank.