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Figure 4 | Malaria Journal

Figure 4

From: Transcription of the var genes from a freshly-obtained field isolate of Plasmodium falciparum shows more variable switching patterns than long laboratory-adapted isolates

Figure 4

Diagram depicting the variable var gene switching patterns of the four clones and the replicates. The second dominant var gene was identified when its transcription level reached 40% of that of the dominant var gene. Clone 4C: var167 switches to var21 in 4C-A, 4C-D, var143 in 4C-C, and var98 in 4C-B. However, at the last time point, the dominant var gene in 4C-A, 4C-B, both switch to var45. Clone 4H: var15 is maintained for over 50 generations in 4H-A, 4H-B, however, its expression falls in 4H-C, 4H-D, switches to var21 in 4H-C. Clone5H: var51 switches off quickly and immediately switches to var21 in 5H-A, 5H-B, but in 5H-C, 5H-D, var51 slows down the off rate and switches to var45, var212. Clone 6G: var47 switches to var136 in 6G-A and var21 in 6G-B. The change in the transcriptional trend is similar in 6G-C and 6G-D; var47 switches to var163 gradually. var51 and var47 were predicted to be upsC and upsB group individually, var167 and var15 should belong to either upsB or upsC but not upsA group from the phylogenetic trees of all var-DBLα-contig amino acid sequences of the wild isolate.

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