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Table 1 Variability in on/off rates of the var genes over 20 generations

From: Transcription of the var genes from a freshly-obtained field isolate of Plasmodium falciparum shows more variable switching patterns than long laboratory-adapted isolates

  

Fast

  

Slow

  

On/off rate

Var gene

Clone

Change of proportional var transcript levels*

Mean rate

Clone

Change of proportional var transcript levels*

Mean rate

On rate

var98

4C-B

2%-29%-42%

2%

4C-D

2.3%-8%-11%

0.44%

 

var45

5H-C

1%-6%-57%

2.8%

5H-D

0.14%-0.26%-2.24%

0.11%

 

var136

6G-A

2%-16%-48%

2.3%

6G-D

1%-1%-1.7%

0.04%

 

var21

5H-B

13%-14%-74%

3.05%

5H-C

11%-17%-25%

0.7%

Off rate

var98

4C-B

42%-32%-11%

1.55%

5H-D

2.5%-1.5%-1.3%

0.06%

 

var51

5H-A

44%-33%-3%

2.05%

5H-B

5.2%-0.8%-0.1%

0.26%

 

var167

4C-C

44%-18%-14%

1.5%

6G-D

1.5%-0.9%-0.5%

0.05%

 

var47

6G-B

34%-20%-19%

0.75%

4C-C

0.9%-0.5%-0.4%

0.03%

  1. Var genes can switch on/off quickly or slowly. The mean on/off rates were calculated according to the change of proportional var transcript levels over the 20 generations.
  2. *during 20 generations.