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Figure 6 | Malaria Journal

Figure 6

From: Protection of Malian children from clinical malaria is associated with recognition of multiple antigens

Figure 6

Relationship between strong humoral responses to multiple antigens and risk of clinical malaria. Children who developed parasitaemia by PCR or thick smear during follow-up (n = 91) were divided into asymptomatic children who experienced no clinical episode of malaria during the transmission season (n = 47), and children who had a symptomatic malaria episode at least once during the transmission season (n = 44). For both groups, the percentage of children strongly recognizing 0 or more antigens is shown at (A) enrollment, (B) in the beginning and (C) after the transmission season. An arbitrary cut-off of 10 AU was used for each antigen. Horizontal bars indicate the percentage of children in each group recognizing three or more antigens strongly. The number of antigens to which high reactivity (>10 AU) was observed was analysed as count data by Poisson regression. (D) The risk of developing clinical malaria during the transmission season was calculated by logistic regression analysis for children that were high responders (>10A AU) for 1, 2, 3, 4 or 5 antigens simultaneously in reference to those that recognized not a single antigen strongly, with adjustment for age. Analysis was performed either prospectively (using December 2011 or July 2012, i.e. before clinical episodes were recorded, excluding one volunteer that experienced a clinical episode in July from the analysis), or retrospectively (using post-season February 2013 antibody titers). Symbols depict odds ratios, error bars indicate the upper and lower 95% confidence interval.

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