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Table 2 Changes of antibody titers after parasite exposure during the transmission season dependent on baseline reactivity

From: Protection of Malian children from clinical malaria is associated with recognition of multiple antigens

 

AMA-1

MSP-1 19

MSP-3

CSP

GLURP-R0

<1 AU

n = 21a

n = 28

n = 1

n = 6

n = 15

July 2012 median [IQR]

0.094 [0.01-0.25]

0.22 [0.01-0.6]

 

0.73 [0.50-0.86]

0.48 [0.2-0.62]

Feb 2013 median [IQR]

0.34 [0.09-2.0]

0.95 [0.05-2.0]

 

1.99 [1.39-2.24]

1.30 [0.88-2.16]

p-value b

0.002

<0.0001

n.d.

0.03

0.002

1-10 AU

n = 28

n = 39

n = 43

n =59

n = 56

July 2012 median [IQR]

3.0 [1.62-6.89]

2.5 [1.35-4.72]

5.05 [3.75-7.23]

4.16 [1.88-6.98]

3.15 [2.12-4.90]

Feb 2013 median [IQR]

4.4 [1.91-10.05]

2.46 [1.08-4.21]

7.21 [4.87-12.73]

4.66 [2.19-8.12]

3.06 [2.08-6.05]

p-value b

0.067

0.96

<0.0001

0.11

0.33

>10 AU

n = 42

n = 24

n = 47

n = 26

n = 20

July 2012 median [IQR]

37.1 [15.1-75.7]

23.9 [16.1-68.9]

29.8 [16.1-82.2]

14.7 [11.7-22.4]

22.4 [13.3-57.6]

Feb 2013 median [IQR]

36.1 [11.1-108.8]

15.3 [6.9-46.2]

19.9 [9.7-51.2]

8.1 [3.96-14.1]

20.2 [3.5-89.9]

p-value b

0.45

0.047

0.002

<0.0001

0.59

  1. a91 children that experiences parasitaemia detected by qPCR or thick smear where included in this analysis.
  2. bAntibody reactivity was compared between July and February for each group and antigen by Wilcoxon matched-pairs signed rank test.