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Table 1 Base case data inputs for epidemiology, health outcomes and diagnostic test characteristics

From: Cost-effectiveness analysis of malaria rapid diagnostic test incentive schemes for informal private healthcare providers in Myanmar

Parameter

Input value

Source

Epidemiology

Percentage of P. falciparum (P.f.)/P. vivax (P.v.) malaria

65% P.f./35% P.v.

Published data [23], PSI Myanmar stock audit data

Proportion of febrile cases in population that are malaria

8%

PSI Myanmar MIS data (Sun Primary Health)

Average number of febrile patients that visit one private provider per month

20

PSI Myanmar MIS data (Sun Primary Health)

Health outcomes

Case fatality rates for P. falciparum malaria

Given ACT

0.01%

Very low probability

Given chloroquine or quinine

0.7%

Published data on falciparum drug resistance [24]

Given no anti-malarial

3%

Published case fatality rates in Bago [25] and on eastern border of Myanmar [26]

Case fatality rates for P. vivax

Given ACT

0.01%

Very low probability

Given chloroquine or quinine

0.01%

Published P. vivax treatment rates with chloroquine in Papua [27]

Given no anti-malarial

1%

Extrapolated from published materials from Papua [28]

Case fatality rate for non-malarial febrile illnesses

Given ACT or other anti-malarial

0.2%

Published data from Bago, Myanmar [25] triangulated with PSI MIS data

Given no anti-malarial

0.16%

Published data on burden of disease in Myanmar [29] and non-malarial fevers in Laos [30]

Average duration of malaria illness without effective treatment

1 week

Published data on hospital records in Myanmar [31]

Average duration of non-malarial febrile illness

1 week

Assumption

DALY weight of malaria

0.2

Published data [21]

DALY weight of non-malarial fever

0.18

Estimated from published data [22]

Mean life expectancy in Myanmar

62 years

Average from 3 studies [32-34]

Average age of malaria-induced death in intervention townships

25 years

PSI Myanmar MIS data

Average age of non-malarial febrile death in Myanmar

30 years

PSI Myanmar MIS data

Discount rate

3%

Standard rate

Diagnostic test characteristics

RDT sensitivity and specificity

P. falciparum sensitivity

100%

Published RDT performance [35]

P. falciparum specificity

97%

Published RDT performance [35]

Pan plasmodium sensitivity

92%

Published RDT performance [35]

Pan plasmodium specificity

98%

Published RDT performance [35]