Figure 2
From: A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail
A representation of putrescine and dcAdoMet within their binding cavities. Residues important for catalysis are shown in green. Red arrows indicate the proposed attack by the putrescine amino group (attacking nitrogen) on the methylene carbon of the aminopropyl chain of dcAdoMet resulting in the catalysis that produces spermidine via a SN2 reaction. Highlighted in cyan is the aminopropyl cavity (in the vicinity of the non-attacking nitrogen of putrescine) that can be accommodated by the aminopropyl chain of spermidine to catalyze the production of spermine.