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Figure 5 | Malaria Journal

Figure 5

From: A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail

Figure 5

Pf SpdS co-crystallized with MTA and compound 8. (A) The electron densities of MTA and compound 8 are shown in blue (σ = 1). The residues involved in hydrogen bonding with compound 8 are indicated with dotted lines. The gate-keeping loop covering the active site is shown as a grey ribbon with two of its residues, Ser197 and Asp199, which together with residues Glu46, Tyr102, His103, Asp127 Asp196, Glu231 and Tyr264, forms the active site. The solvent molecule involved in an interaction with compound 8 via Glu46 is shown as a yellow sphere. (B) MTA and compound 8 of the 3RIE structure in grey are superimposed with 4MCHA and dcAdoMet in green from the 2PT9 crystal structure. The active site residues involved in compound 8 and 4MCHA binding are shown in grey and cyan, respectively.

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