Skip to main content
Figure 6 | Malaria Journal

Figure 6

From: A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail

Figure 6

Different binding poses that compounds 8 (green) and 9 (white) can assume upon binding with MTA and dcAdoMet, respectively. (A) Compounds 8 and 9 traverse the catalytic centre when cooperatively bound with MTA. The aminopropyl chains of compounds 8 and 9 bind in the chemical space that are normally occupied by the aminopropyl chain of dcAdoMet. (B) Compound 8 and 9 assume a reverse binding pose in the presence of dcAdoMet. Compounds 8 and 9 form hydrogen bonds with Asp199 and a water molecule anchored by Ile92 and Glu46 (not shown) in the non-attacking end of the putrescine-binding cavity. An additional hydrogen bond is formed by compound 9 with Tyr102.

Back to article page