Figure 7
From: A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail
A schematic representation of the binding poses of putrescine spermidine, spermine, compound 8 and compound 9 to SpdS. The grey highlighted columns depict the two different binding pockets for the aminopropyl chains of spermidine, spermine, compound 8 and compound 9. The grey column on the left depicts the aminopropyl binding pocket associated with the dcAdoMet binding cavity. The grey column on the right depicts the additional aminopropyl binding pocket located in the non-attacking end of the putrescine binding cavity responsible for the ability of PfSpdS to produce spermine. The white column depicts the putrescine binding cavity and the corresponding moieties of the analogues depicted in this Figure. PDB IDs are given when the binding poses of compounds were from crystal structures. When ligands are resolved in the presence of MTA or dcAdoMet they are indicated in the aminopropyl binding pocket column of dcAdoMet (grey column on the left). For compounds resolved with dcAdoMet their aminopropyl chains are displayed in their binding cavities. R1 = NH3 + is compound 8; R1 = H is compound 9.