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Table 1 Effects of various inhibitors on Plasmodium falciparum spermidine synthase

From: A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail

 

Mammalian

P. falciparum

Inhibitor

Enzyme inhibition, IC 50 (μM)

Enzyme inhibition, IC 50 (μM)

4MCHA

1.7†

1.4 ± 0.1*

Cyclohexylamine

8.1§

19.7 ± 3.1*

APE

1.7┴

6.5 ± 2.1*

AdoDATO

0.05-0.10†

8.5#

Adenosylspermidine

0.014†

N.D.

MTA

N.D

159 ± 27*

Compound 8

N.D.

619 ± 144a

Compound 9

N.D.

7.4 ± 2.4a

  1. aResults are the mean of at least three independent, duplicate experiments ± SEM.
  2. *Haider et al. [18].
  3. #Dufe et al. [20].
  4. §Shirahata et al. [22].
  5. †Lakanen et al. [21]; Pegg et al. [38].
  6. ┴Goda et al. [39].
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Malaria Journal

ISSN: 1475-2875

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