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Table 6 Neurodevelopmental assessment according to anti-malarial drug exposure during first trimester

From: Exposure to artemether-lumefantrine (Coartem®) in first trimester pregnancy in an observational study in Zambia

 

Exposure group

 

AL only

AL and SP

SP and/or quinine

No anti-malarial

Unknown anti-malarial

14 weeks after delivery

N=81, Median (range)

N=3, Median (range)

N=48, Median (range)

N=367, Median (range)

N=22, Median (range)

Motor milestones

9.0

12.0

7.0

9.0

11.5

(6.0-18.0)

(12.0-13.0)

(5.0-37.0)

(2.0-18.0)

(6.0-24.0)

Coordination

5.0

10.0

5.0

6.0

6.0

(4.0-20.0)

(5.0-11.0)

(4.0-34.0)

(2.0-21.0)

(6.0-6.0)

Tone

18.0

18.0

18.0

18.0

17.5

(15.0-23.0)

(17.0-19.0)

(16.0-20.0)

(13.0-24.0)

(14.0-23.0)

Behaviour

15.0

15.0

15.0

15.0

15

(12.0-15.0)

(15.0-15.0)

(10.0-15.0)

(10.0-15.0)

(12.0-15.0)

14 weeks after delivery

N=81, Mean (SD)

N=3, Mean (SD)

N=48, Mean (SD)

N=367, Mean (SD)

N=22, Mean (SD)

Height (cm)

59.9 (4.11)

59.6 (4.13)

59.2 (4.17)

59.6 (4.15)

59.8 (4.12)

Weight (kg)

6.7 (0.94)

6.6 (0.99)

6.6 (0.93)

6.6 (0.93)

6.6 (0.98)

One year after delivery

N=75, Median (range)

N=3, Median (range)

N=49, Median (range)

N=365, Median (range)

N=20, Median (range)

Motor milestones

35.0

35.0

34.0

35.0

35.0

(25.0-37.0)

(31.0-37.0)

(25.0-37.0)

(20.0-37.0)

(28.0-37.0)

Coordination

32.0

26.0

32.0

32.0

31.0

(19.0-34.0)

(26.0-32.0)

(5.0-33.0)

(12.0-34.0)

(21.0-33.0)

Tone

20.0

18.0

19.0

20.0

18.0

(16.0-20.0)

(17.0-20.0)

(16.0-20.0)

(15.0-24.0)

(16.0-24.0)

Behaviour

15.0

15.0

15.0

15.0

15.0

(12.0-15.0)

(15.0-15.0)

(7.0-15.0)

(9.0-15.0)

(13.0-15.0)

One year after delivery

N=75, Mean (SD)

N=3, Mean (SD)

N=49, Mean (SD)

N=365, Mean (SD)

N=20, Mean (SD)

Height (cm)

70.5 (6.46)

69.0 (6.32)

68.9 (6.22)

70.0 (6.43)

69.0 (6.35)

Weight (kg)

9.5 (1.08)

9.4 (1.08)

9.4 (1.09)

9.3 (1.09)

9.4 (1.08)

  1. Neurodevelopmental assessment done in only 60% of all study participants.