|
pfmdr1
haplotype
a
|
86
|
184
|
1034
|
1042
|
1246
|
No. mutations
|
Asembo, N (%)
|
Gem, N (%)
|
Karemo, N (%)
|
|---|
|
(n = 47)
|
(n = 75)
|
(n = 70)
|
|---|
|
Wild type
|
N aat
|
Y tat
|
S agt
|
N aat
|
D gat
| | | | |
|
Mutant
|
Y tat
|
F ttt
|
C tgt
|
D gat
|
Y tat
| | | | |
| |
N
|
Y
|
S
|
N
|
D
|
0
|
5 (11)
|
10 (13)
|
9 (13)
|
| |
N
|
Y
|
S
|
N
|
Y
|
1
|
2 (4)
|
8 (11)
|
2 (3)
|
| |
N
|
F
|
S
|
N
|
D
|
1
|
5 (11)
|
6 (8)
|
7 (10)
|
| |
Y
|
Y
|
S
|
N
|
D
|
1
|
16 (34)
|
20 (27)
|
22 (31)
|
| |
N
|
F
|
S
|
N
|
Y
|
2
|
1 (2)
|
3 (4)
|
1 (1)
|
| |
Y
|
F
|
S
|
N
|
D
|
2
|
2 (4)
|
6 (8)
|
7 (10)
|
| |
Y
|
Y
|
S
|
N
|
Y
|
2
|
16 (34)
|
17 (23)
|
19 (27)
|
| |
Y
|
F
|
S
|
N
|
Y
|
3
|
0 (0)
|
5 (7)
|
3 (4)
|
-
Note. No. = number. Wild type amino acids are shown in normal font, while mutated amino acids are depicted in bold font.
-
a The construction of the pfmdr1 haplotype included codons 86, 184, 1034, 1042, and 1246. All isolates coded for wild type S1034 and N1042.
