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Table 4 Haplotypes for dhfr and dhps resistance markers combined at the 2007 survey in western Kenya, by study area

From: Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya

SP haplotype a dhfr 51 dhfr 59 dhfr 108 dhfr 164 dhps 436 dhps 437 dhps 540 No. mutations Asembo, N (%) (n = 17) Gem, N (%) (n = 32) Karemo, N (%) (n = 25)
Wild type N aat C tgt S agc I ata S tct A gct K aaa     
Mutant I att R cgt N aac L tta A gct G ggt E gaa     
  I R N I S A K 3 0 (0) 0 (0) 1 (4)
  N R N I S G E 4 2 (12) 0 (0) 0 (0)
  I C N I S G E 4 3 (18) 6 (19) 5 (20)
  I R N I S G K 4 0 (0) 1 (3) 0 (0)
  I R N I S A E 4 1 (6) 0 (0) 0 (0)
  I R N I S G E 5 11 (65) 23 (72) 19 (76)
  I C N L S G E 5 0 (0) 1 (3) 0 (0)
  I R N I A G E 6 0 (0) 1 (3) 0 (0)
  1. Note. SP = sulphadoxine-pyrimethamine; No. = number. Wild type amino acids are shown in normal font, while mutated amino acids are depicted in bold font. All samples were single infection for the microsatellite marker poly-α.
  2. aThe construction of the SP haplotype included dhfr-50, 51, 59, 108, 164 and dhps-436, 437, 540, 581, 613. All samples coded for wild type C at dhfr-50, A at dhps-581, and A at dhps-613.