Table 1 Ex vivo susceptibility of 18 Plasmodium falciparum isolates from Dakar to chloroquine (CQ), monodesethylamodiaquine (MDAQ), lumefantrine (LMF), dihydroartemisinin (DHA), quinine (QN), mefloquine (MQ), artesunate (AS), pyronardine (PND), piperaquine (PPQ) and Proveblue (PVB)
Drug | Isolate IC 50 | Resistance or reduced susceptibility | ||||
|---|---|---|---|---|---|---|
Mean | CI 95% | Min | Max | Cut-off | % | |
CQ | 52.2 nM | 29.1-93.9 | 6.1 | 346.4 | 77 nM | 50.0 |
MDAQ | 9.8 nM | 5.5-17.4 | 1.9 | 117.1 | 61 nM | 5.6 |
LMF | 4.1 nM | 2.1-8.1 | 0.61 | 82.9 | 115 nM | 0 |
DHA | 0.72 nM | 0.35-1.50 | 0.1 | 5.08 | 12 nM | 0 |
AS | 1.35 nM | 0.53-3.42 | 0.12 | 5.53 | 12 nM | 0 |
QN | 63.1 nM | 30.9-128.7 | 6.2 | 1430 | 611 nM | 5.6 |
MQ | 30.1 nM | 19.4-46.6 | 7.1 | 63.4 | 30 nM | 55.6 |
PND | 5.8 nM | 3.3-10.1 | 0.4 | 19.7 | ND | ND |
PPQ | 32.2 nM | 16.5-62.8 | 2.5 | 168.0 | ND | ND |
PVB | 5.3 nM | 2.8-10.1 | 0.9 | 40.2 | ND | ND |