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Table 4 RDT performance compared with matching microscopy and qPCR (n = 415) for all infections regardless of parasite density

From: Comparison of rapid diagnostic test Plasmotec Malaria-3, microscopy, and quantitative real-time PCR for diagnoses of Plasmodium falciparum and Plasmodium vivax infections in Mimika Regency, Papua, Indonesia

RDT performance

Plasmodium falciparum (n = 88 microscopy +)

Plasmodium vivax (n = 85 microscopy +)

Plasmodium falciparum (n = 88 qPCR +)

Plasmodium vivax (n = 94 qPCR +)

Prevalence

21.2%

20.5%

21.2%

22.6%

Sn*

92% (84.3-96.7%)

72.9% (62.2-82%)

92% (84.3-96.7%)

66% (55.5-75.4%)

Sp*

96.6% (94.1-98.3%)

99.1% (97.4-99.8%)

96.6% (94.1-98.3%)

99.1% (97.3-99.8%)

PPV*

88% (79.6-93.9%)

95.4% (87.1-99%)

88% (79.6-93.9%)

95.4% (87.1-99.0%)

NPV*

97.8% (95.6-99.1%)

93.4% (90.3-95.8%)

97.8% (95.6-99.1%)

90.9% (87.3-93.7%)

PLR*

27.4 (15.3-49.1)

80.2 (25.8-249)

27.4 (15.3-49.1)

70.6 (22.7-220)

NLR*

0.08 (0.04-0.17)

0.27 (0.19-0.39)

0.08 (0.04-0.17)

0.34 (0.26-0.46)

Kappa

0.87

0.79

0.87

0.73

  1. Sn = sensitivity; Sp = specificity; PPV = positive predictive value; NPV = negative predictive value; PLR = positive likelihood ratio; NLR = negative likelihood ratio.
  2. *95% CI.