Early treatment failure (ETF) | ● Signs of severe malaria/clinical deterioration requiring rescue medication on Days 0, 1, 2 or 3, in the presence of P. falciparum parasitaemia* |
● Last available asexual P. falciparum parasite count on Day 2 greater than the first available parasite count at baseline irrespective of axillary, oral, or rectal temperature | |
● Parasitaemia (P. falciparum) on Day 3 with fever† | |
● Last available P. falciparum parasite count on Day 3 ≥ 25% of the first available parasite count at baseline | |
Late treatment failure | |
Late clinical failure (LCF) | ● Signs of severe malaria/ clinical deterioration requiring rescue medication after Day 3 in the presence of P. falciparum parasitaemia, without previously meeting any of the criteria of ETF |
● Presence of P. falciparum parasitaemia and fever† on any day from Day 4 onward, without previously meeting any of the criteria of ETF | |
Late parasitologic failure | ● Presence of P. falciparum parasitaemia on any day from Day 7 onward and the absence of fever without previously meeting any of the criteria of ETF or LCF |