Table 1 Effect of chloroquine on RAS protective efficacy
No. protected/ no. challenged | |||||
|---|---|---|---|---|---|
Immunization | Mouse strain | Immunization dose (x10 3 RAS PbSPZ) | Inoculations (n) | Chloroquine - | Chloroquine + # |
RAS | Balb/cByJ | 1 | 1 | 14/16 (88) | 13/16 (81) |
0.5 | 1 | 4/10 (40) | 4/10 (40) | ||
0.3 | 1 | 5/10 (50) | 2/10 (20) | ||
C57BL/6j | 10 | 3 | 5/5 (100) | 4/5 (80) | |
4 | 3 | 4/5 (80) | 4/5 (80) | ||
1 | 3 | 0/5 (0) | 1/5 (20) | ||
4 | 2 | 15/23 (65) | 14/23 (61)## | ||
None | Balb/cByJ | N/A | N/A | 1/6 (16) | 0/6 (0) |
C57BL/6j | N/A | N/A | 0/10 (0) | 0/15 (0) | |