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Table 1 Effect of chloroquine on RAS protective efficacy

From: Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria

     No. protected/ no. challenged
Immunization Mouse strain Immunization dose (x10 3 RAS PbSPZ) Inoculations (n) Chloroquine - Chloroquine + #
RAS Balb/cByJ 1 1 14/16 (88) 13/16 (81)
   0.5 1 4/10 (40) 4/10 (40)
   0.3 1 5/10 (50) 2/10 (20)
  C57BL/6j 10 3 5/5 (100) 4/5 (80)
   4 3 4/5 (80) 4/5 (80)
   1 3 0/5 (0) 1/5 (20)
   4 2 15/23 (65) 14/23 (61)##
None Balb/cByJ N/A N/A 1/6 (16) 0/6 (0)
  C57BL/6j N/A N/A 0/10 (0) 0/15 (0)
  1. #Mice received chloroquine prophylaxis for 10 or 17 days, with the exception of the experiment indicated with ##, where mice received two injections of CQ, 2 h before and 6 h after each immunization.