Adverse event pattern. Adverse event (AE) episodes are given over time from Day 0 through Day 21. Shades of blue represent AE grading from Grade 1 (dark), to Grade 2 (blue), to Grade 3 (light blue). Volunteer IDs with a star indicate those volunteers who did not develop parasitaemia. The time of parasite detection by microscopy is given as the letter ‘M’ in red.