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Table 3 Infection rate, pre-patent period and time to malaria

From: Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres

Group

Inoculated (N)

Parasitaemic (N)

Prepatent period in days* (Days)

Incubation period ‡ (Days)

ID 2500

6

4

13.6 (12.3 – 15.3)

14.2 (13.0 – 16.0)

IV 50

3

1

13.3 (NA)

7.5 (NA)

IV 200

3

1

13.9 (NA)

15.0 (NA)

IV 800

9

7

11.7 (10.9 – 12.5)

12.0 (11.0 – 13.5)

IV 3200

9

9

11.2 (10.5 – 12.5)

9.5 (7.0 – 12.5)

DVI 3200

6

6

11.4 (10.4 – 12.3)

10.6 (10.0 – 12.0)

  1. *Time from inoculation to first positive thick blood smear, given as geometric mean (min–max).
  2. ‡Time from inoculation to first symptom judged at least possibly related to malaria, given as geometric mean (min–max).
  3. NA: not applicable, ID: intradermal, IV: intravenous, DVI: direct venous inoculation (verification group).
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Malaria Journal

ISSN: 1475-2875

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