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Table 6 Outcomes of severe malaria cases a

From: Severe malaria in Canada, 2001–2013

 

All severe cases no./no. (%)

IV-Artesunate no./no. (%)

IV-Quinine no./no. (%)

P value

Hospitalization, days, median (range) (n=133)

4

(0–28)

4

(0–28)

4

(0–27)

0.070

Intensive care unit stay, days, median (range) (n=134)

1

(0–19)

0

(0–17)

3

(0–19)

0.045

Negative blood smear, days, median (range) (n=104)

3

(0–21)

2

(0–8)

4

(1–21)

0.000

Stepdown therapy

130/150

(87)

88/99

(89)

42/51

(82)

0.265

IV adverse events

15/131

(11)

7/89

(8)

8/42

(19)

0.061

Minor complication

5/131

(4)

2/89

(2)

3/42

(7)

0.327

Serious complication

4/131

(3)

3/89

(3)

1/42

(2)

1.000

Other complication

6/131

(5)

2/89

(2)

4/42

(10)

0.083

Outcome

       

Still hospitalized

27/143

(18)

16/92

(17)

11/51

(22)

0.514

Discharged

100/143

(70)

64/92

(70)

36/51

(71)

0.898

Deceased

3/143

(2)

1/92

(1)

2/51

(4)

0.257

  1. aThree cases were started on IV quinine and transferred to IV artesunate. To simplify analysis, those cases were classified as having received IV artesunate therapy alone. None had adverse events or negative outcomes.