Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon

Table 3 Oxidative stress parameters of mice from both groups

Groups	NN (μM)		TBARS (μg/L)		TEAC (mM/L)
Groups	Brain	Lung	Brain	Lung	Brain	Lung
Infected	507.3 ± 52.2	408.8 ± 49.1	224.8 ± 66.2	86.9 ± 40.5	20.0 ± 3.4	11.0 ± 3.3
EEHa	315.8 ± 57.0*	257.8 ± 48.0*	258.2 ± 57.7^NS	38.0 ± 16.2*	21.5 ± 5.2^NS	6.1 ± 9.6^NS

Values are presented as mean ± standard deviation (n = 10 animals). Infected Group: Plasmodium berghei-infected mice; EEHa: Plasmodium berghei-infected mice and treated with EEHa (ethanol extract from Himatanthus articulatus stem bark) 200 mg/Kg, orally. NN: nitrite/nitrate; TBARS: thiobarbituric acid reactive substances; TEAC: Trolox® Equivalent Antioxidant Capacity. *p < 0.05 versus Infected Group. ^NSNon-significant versus Infected Group. Student’s. “t” Test.

ISSN: 1475-2875