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Table 5 Laboratory patterns of 38 days EEHa-treated mice

From: Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon

Laboratory Parameters

Males (n = 8)

Females (n = 8)

C

T200

T100

S

C

T200

T100

S

AST (UI/L)

136.7 ± 52.3

111.0 ± 56.6

147.0 ± 59.6

82.2 ± 17

83.5 ± 6.4

124.0 ± 18.4 *

65.0 ± 32.4

88.3 ± 19.5

ALT (UI/L)

7.7 ± 2.9

8.2 ± 1.7

7.5 ± 1.3

8.2 ± 2.1

16.0 ± 1.4

7.0 ± 1.4*

6.0 ± 0.0 *

6.4 ± 0.9*

ɣGT (UI/L)

11.5 ± 10.6

4.0 ± 0.0

4.2 ± 0.4

4.0 ± 0.0

4.0 ± 0

4.3 ± 0.6

4.0 ± 0.0

4.0 ± 0.0

Alb (g/dL)

2.9 ± 0.4

2.3 ± 0.2 *

2.6 ± 0.1

2.4 ± 0.2

3.4 ± 0.9

2.4 ± 0.5

2.4 ± 0.4

2.4 ± 0.2

TP (g/dL)

6.4 ± 2,35

4.2 ± 0.2*

4.3 ± 0.1

4.5 ± 0.4

4.7 ± 0.6

3.6 ± 0.7

3.9 ± 0.3

4.7 ± 0.3

TC (mg/mL)

95.0 ± 15.4

83.7 ± 3.2

86.0 ± 4.2

86.7 ± 4.3*

99.3 ± 10.0

66.6 ± 7.6*

83.5 ± 5.8

67.3 ± 3.2*

TGD (mg/mL)

163.0 ± 31.1

205.7 ± 15.0*

185.3 ± 12.7

229.7 ± 2.5*

173.3 ± 17.8

132.5 ± 17.7

154.0 ± 12.1

163.8 ± 18,5

  1. EEHa: Ethanol extract from Himatanthus articulatus stem bark; AST-aspartate aminotransferase; ALT-alanine aminotransferase; ɣGT- gamma glutamyl transferase; Alb- albumin; TP- total protein; TC- Total cholesterol; TGD- triglycerides; Ur- urea; UA- uric acid; C- control group; T200- group treated orally with EEHa (200 mg/Kg); T100- group treated orally with EEHa (100 mg/Kg); S- satellite group. *p < 0.05 versus control group.