Table 3 The frequency of kdr mutations in the Anopheles sinensis samples in central China
Sample code | Sample location | Sample size | Wildtype | Wildtype/mutant heterozygote | Mutant genotype | Mutation frequency (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mutant homozygote | Mutant heterozygote | ||||||||||||
TTG(L)/ TTG(L) | TTG(L)/ TTT(F) | TTG(L)/ TTC(F) | TTG(L)/ TGT(C) | TTT(F)/ TTT(F) | TTC(F)/ TTC(F) | TGT(C)/ TGT(C) | TTT(F)/ TTC(F) | TTT(F)/ TGT(C) | TTC(F)/ TGT(C) | ||||
1997-2001 | |||||||||||||
ZZ97 | Henan | 9 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 |
XY97 | Jiangsu | 20 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |
WJ97 | Jiangsu | 24 | 19 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 20.83 |
JN97 | Shandong | 3 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 33.33 |
JN00 | Shandong | 31 | 17 | 4 | 0 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 45.16 |
NY01 | Henan | 23 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 |
Total | 110 | 89 | 7 | 0 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 19.09 | |
Genotype frequency(%) | 80.91 | 6.36 | 0.00 | 12.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |||
2005-2009 | |||||||||||||
HF06 | Anhui | 19 | 1 | 4 | 0 | 3 | 8 | 0 | 0 | 0 | 3 | 0 | 94.74 |
WH06 | Hubei | 24 | 0 | 3 | 0 | 4 | 5 | 0 | 5 | 0 | 7 | 0 | 100.00 |
SZ07 | Hubei | 13 | 3 | 4 | 0 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | 76.92 |
ZZ07 | Henan | 10 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 30.00 |
JN07 | Shandong | 22 | 1 | 0 | 0 | 0 | 16 | 0 | 0 | 0 | 5 | 0 | 95.45 |
JX09 | Jiangxi | 16 | 0 | 0 | 0 | 0 | 12 | 0 | 0 | 0 | 3 | 1 | 100.00 |
Total | 104 | 12 | 11 | 0 | 8 | 43 | 0 | 5 | 0 | 24 | 1 | 88.46 | |
Genotype frequency(%) | 11.54 | 10.58 | 0.00 | 7.69 | 41.35 | 0.00 | 4.81 | 0.00 | 23.08 | 0.96 | |||
2010-2014 | |||||||||||||
JN12 | Shandong | 12 | 0 | 0 | 0 | 0 | 7 | 0 | 1 | 0 | 4 | 0 | 100.00 |
CX12 | Shandong | 30 | 1 | 11 | 0 | 6 | 10 | 0 | 0 | 0 | 2 | 0 | 96.67 |
JD12 | Shanghai | 24 | 0 | 0 | 0 | 0 | 12 | 0 | 1 | 0 | 10 | 1 | 100.00 |
HS13 | Anhui | 60 | 0 | 2 | 0 | 0 | 28 | 1 | 4 | 3 | 20 | 2 | 100.00 |
XC13 | Anhui | 30 | 0 | 0 | 0 | 0 | 15 | 0 | 2 | 0 | 13 | 0 | 100.00 |
Total | 156 | 1 | 13 | 0 | 6 | 72 | 1 | 8 | 3 | 49 | 3 | 99.36 | |
Genotype frequency(%) | 0.64 | 8.33 | 0.00 | 3.85 | 46.15 | 0.64 | 5.13 | 1.92 | 31.41 | 1.92 | |||