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Table 1 Study design and baseline characteristics of efficacy trials that assessed AL and AS + AQ

From: Monitoring of efficacy and safety of artemisinin-based anti-malarials for treatment of uncomplicated malaria: a review of evidence of implementation of anti-malarial therapeutic efficacy trials in Tanzania

Study ID Authors Year of study Study duration in months Study site Randomization Sample size Days of follow-up Parasitaemia inclusion criteria/μl Pf- GMPD Supervised
TZ001_AL Martensson et al. [31] 2002-2003 4 Zanzibar Yes, two arms 200 42 2,000-200,000 13,731 Yes
TZ001_ AS + AQ Martensson et al. [31] 2002-2003 4 Zanzibar Yes, two arms 208 42 2,000-200,000 19,731 Yes
TZ002_AL Mutabingwa et al. [40] 2002-2004 26 Muheza Yes, four arms 519 28 ≥2,000 19,280 No
TZ002_ AS + AQ Mutabingwa et al. [40] 2002-2004 26 Muheza Yes, four arms 515 28 ≥2,000 18,920 No
TZ003_AL Kabanywanyi et al. [39] 2004 7 Kyela Yes, four arms 99 28 2,000-200,000 43,115 Yes
TZ003_AS + AQ Kabanywanyi et al. [39] 2004 7 Kilombero Yes, four arms 76 28 2,000-200,000 49,348 Yes
TZ004_AL Sykes et al. [41] 2008 7 Muheza Yes, two arms 132 42 2,000-200,000 24,280** Partial
TZ004_AZ + AS Sykes et al. [41] 2008 7 Muheza Yes, two arms 129 42 2,000-200,000 20,960** Partial
TZ005_AL Ngasala et al. [36] 2007-2008 12 Bagamoyo Yes, two arms 180 56 2,000-200,000 41,885 Yes
TZ005*_AL Ngasala et al. [36]* 2007-2008 12 Bagamoyo Yes, two arms 179 56 2,000-200,000 38,272 No
TZ006_AL Ngasala et al. [37] 2007 6 Kibaha No, single arm 244 42 NR 19,054 No
TZ007_AL Kamugisha et al. [35] 2010-2011 12 Mwanza No, single arm 108 28 2,000-200,000 5,608 Yes
TZ008_AL Joseph et al. [34] 2011 3 Tabora No, single arm 20 28 2,000-200,000 39,400 Partial
TZ009_AL*** Shayo et al. [38] 2013 2 Muheza No, single arm 88 28 250-200,000 18,603 Yes
  1. Doses of AL were given twice a day for three days; Doses of AS + AQ were given once a day for three days;
  2. TZ005_AL was the same study split into supervised and unsupervised*arm; NR = Not reported, Pf-GMPD = P. falciparum geometric mean parasite density of asexual parasites per microlitre of blood. **median parasite counts (asexual parasites per microlitre of blood) reported
  3. ***The study was conducted after malaria transmission had declined in the area and recruited children aged six months to 10 years and low cut-off of parasite density (250 asexual parasites/μl).