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Figure 2 | Malaria Journal

Figure 2

From: Assessing anti-malarial drug effects ex vivo using the haemozoin detection assay

Figure 2

Representative analysis of drug effects assessed after ex vivo culture of blood samples from malaria patients. Representative plots of flow cytometric analysis of an uninfected blood sample (A) and a sample from a malaria patient with 1.5% parasitaemia (B). At time point 0 of incubation, no difference in depolarizing events is observed between the infected samples and the uninfected control (A and B). However, Hz is produced as the parasite matures, and after 24 hrs of incubation an increase in the percentage of depolarizing cells is detected (B) from 0.02 to 0.36. In this example, drug effects could be determined after only 24 hrs of incubation (C). Contrary to chloroquine, where resistance was observed, artesunate and artemisinin are still effective drugs (C).

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