Repertoire of Plasmodium falciparum antigenic diversity recognized by infected children in Gabon. (A) Percentage of individuals in the study population that recognized at least one P. falciparum antigen. (B) Antibody patterns and percentage of positive patients for each of the 20 P. falciparum-specific antigens tested in the total study population. (C) Kruskal-Wallis analysis of the antibody responses against the 20 parasite antigens in all groups. (D) Plasma levels (pg/mL) of anti-P. falciparum MSP3-3D7 antibodies in EC, AM and MM. (E) Single linkage hierarchical clustering of the antibody response against the 20 P. falciparum antigens tested in the different groups. (F) Heat map representing fold change of the antibody response and Mann–Whitney p-value comparing the different groups: AM vs MM, AM vs EC, and EC vs MM. Antigens: MSP1 block 2 PA repeats; MSP1 block 2 3D7 Wellcome repeats; MSP1 block 2 3D7 full length; MSP1 block 2 3D7 Wellcome full length; MSP1 block 2 MAD20 full length; MSP1 block 2 RO33 full length; MSP1 block 2 K1 super repeats; MSP1 block 2 K1 flanking; MSP1 block 2 MAD20 repeats; MSP1 block 2 3D7 repeats; MSP3 3D7; MBP; MSP3 K1; MSP2 3D7; MSP2 FC27; AMA-1; GST; MSP1-19 GST; PfEMP1; NANP.