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Table 2 In vitro anti-malarial activities (IC 50 and IC 90 ) of 10 anti-malaria compounds against the P. falciparum 7G8 cell bank parasites

From: Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccines

Compound Maximal concentration tested (nM) IC 50 (nM) IC 90 (nM)
Average (n = 2) Standard deviation (n = 2) Average (n = 2) Standard deviation (n = 2)
Artemether 50 5.5 2.5 9.4 4.3
Artesunate 50 2.5 0.3 4.6 0.9
DHA 50 2.6 0.7 6.2 1.9
Atovaquone 400 2.1 0.3 5.5 0.3
Mefloquine 200 11.9 0.5 27.3 0.5
Piperaquine 200 46 9 68 3
Lumefantrine 200 34 4 99 13
Chloroquine 1,000 130 6 208 8
Pyrimethamine 5,000 2,799 52 4,080 248
Proguanil 200,000 5,677 617 18,840 5416