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Table 2 Questions raised by volunteers at screening appointments

From: Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya

Question category

Number of questions asked

Percentage (%)

n = 167

Effects of malaria infection and treatment: short and long-term

27

16%

Details of in-patient stay and travel out of Nairobi

20

12%

Availability of test results

19

11%

Blood sampling

13

8%

Further explanation of study logistics

13

8%

Parasite strain used in CHMI

13

8%

Prior studies of PfSPZ Challenge

10

6%

Rationale for allocation to groups

9

5%

Malaria treatment

7

4%

Study start date

7

4%

Compensation

6

4%

Post CHMI follow-up

5

3%

Purpose of the research

4

2%

Possibility of failure of infection

3

2%

Criteria for malaria treatment

3

2%

Failure to cure malaria infection

2

1%

Injection sites of PfSPZ Challenge

2

1%

Proof of participation in the study

2

1%

Resistance of PfSPZ Challenge to anti-Malarial drugs

2

1%