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Table 3 Initial criteria for group allocation according to degree of prior exposure to Plasmodium falciparum

From: Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya

Groups Malaria exposure Anti-Pf serology* History of malaria infection Time spent in endemic region
1, 3, 5 None All negative None Lived whole life in Nairobi or similar area where P. falciparum is not endemic.
2, 4, 6 Maximal High positive +/- Vast majority of life spent in western Kenya in area of high P. falciparum transmission. Immediately prior to CHMI, should not have spent more than 6 months out of endemic region.
  1. *Anti-Pf serology = Anti-schizont and Anti-MSP2 antibodies.