Figure 2

Distribution of the mutations in the predicted 3D model of the K13 propeller domain. The predicted structure of the propeller domain forms six propeller blades that contain predominantly strands. The locations of the various mutations are indicated by spheres, where red colour represents new mutations, orange for previous reported mutations, and pink for mutations correlated with ART resistance reported by Ariey et al. The relative frequencies of the mutations are reflected by the size of the spheres.