Figure 7
From: Novel pantothenate derivatives for anti-malarial chemotherapy
Pantothenate competes with RR8. Competition assay between RR8 and pantothenate (PA), results of Schild analysis. A) Shifting IC50: Combined data points from three experiments. RR8 with 20.0 μM PA, RR8 with 6.3 μM PA, RR8 with 2.0 μM PA, RR8 with 0.6 μM PA and RR8 alone. B) Schild plot: Combined data points from three experiments. A slope of 1 is indicative of a competitive antagonistic relationship between RR8 and PA.