Clinical profile of Plasmodium falciparum and Plasmodium vivax infections in low and unstable malaria transmission settings of Colombia

Table 3 Clinical laboratory parameters

Laboratory parameters	Uncomplicated malaria (n = 1225)		p value ^b	Severe malaria (n = 99)		p value ^b
	Median (IQR ^a )			Median (IQR ^a )
	*P. falciparum*	*P. vivax*		*P. falciparum*	*P. vivax*
Haemoglobin (g/dL)	12.5 (11.2-13.6)	12.7 (11.3-14)	0.024	12.8 (11.5-13.8)	12.8 (10.9-14.2)	ns
Platelets count (x10³/μL)	159 (123.5-209)	150 (112–196.5)	0.008	120 (83–159)	138 (82–660)	ns
Total bilirubin (mg/dL)	0.6 (0.3-0.9)	0.7 (0.4-1.1)	<0.001	1.0 (0.3-2.5)	1.0 (0.5-3.4)	ns
Direct bilirubin (mg/dL)	0.17 (0.08-0.27)	0.18 (0.10-0.32)	0.002	0.25 (0.10-0.98)	0.32 (0.18-0.52)	ns
ALT (U/L)	33 (24–48)	29 (23–38)	<0.001	50 (19–141)	19 (15–38)	0.001
AST (U/L)	21 (14–32)	17 (12–24)	<0.001	75 (32–154)	33 (24–50)	0.001
Creatinine (mg/dL)	1.0 (0.9-1.2)	0.9 (0.8-1.1)	<0.001	1.0 (0.9-1.3)	1.0 (0.8-1.3)	ns

^aIQR, interquartile range; ALT, Alanine aminotransferase; AST, aspartate aminotransferase; ns, not significant. ^bp value using the Mann–Whitney test between P. falciparum and P. vivax. Most frequent and significant data are highlighted in bold.

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