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Table 2 Parasitological cure rates on days 14, 28 and 42

From: Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

Population

PCR-corrected cure rates

PCR-uncorrected cure rates

n (%)

n (%)

(95% CI)

(95% CI)

Day 14

FAS (N = 20)

16 (80)

16 (80)

 

(53.6, 94.3)

(53.6, 94.3)

EPS (N = 16)

16 (100)

16 (100)

 

(79.4, 100)

(79.4, 100)

PPS (N = 16)

16 (100)

16 (100)

 

(79.4, 100)

(79.4, 100)

Day 28

FAS (N = 20)

16 (80)

10 (50)

 

(53.6, 94.3)

(27.2, 72.8)

EPS (N = 16)

16 (100)

10 (62.5)

 

(79.4, 100)

(35.4, 84.8)

PPS (N = 16)

16 (100)

10 (62.5)

 

(79.4, 100)

(35.4, 84.8)

Day 42

FAS (N = 20)

16 (80)

7 (35)

 

(53.6, 94.3)

(15.4, 59.2)

EPS (N = 16)

16 (100)

7 (43.8)

 

(79.4, 100)

(19.8, 70.1)

PPS (N = 16)

16 (100)

7 (43.8)

 

(79.4, 100)

(19.8, 70.1)

  1. CI, Exact Pearson-Clopper two-sided 95% confidence limits; EPS, evaluable population set; FAS, full analysis set; PPS, per protocol set.
  2. Parasitaemia results were taken from the central microscopy reading.