Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

Table 4 Patients with haematologic and blood chemistry abnormalities

		Day 3	Day 7	Day 14	Day 28	Day 42
		n (%)	n (%)	n (%)	n (%)	n (%)
Haematology parameters
Haemoglobin	Low	1 (6.3)	2 (10.5)	1 (8.3)	1 (12.5)	1 (25.0)
Haemoglobin	High	0	0	0	0	0
Haematocrit	Low	1 (6.3)	1 (5.3)	1 (8.3)	1 (12.5)	0
Haematocrit	High	0	0	0	0	0
Neutrophils	Low	3 (18.8)	3 (17.6)	2 (20.0)	2 (25.0)	0
Neutrophils	High	0	1 (5.9)	0	0	1 (25.0)
Platelets	Low	1 (6.3)	1 (6.3)	1 (10.0)	1 (12.5)	0
Platelets	High	0	4 (25.0)	5 (50.0)	0	2 (50.0)
Blood chemistry parameters
Bilirubin (total)	Low	1 (6.3)	0		0	0
Bilirubin (total)	High	2 (12.5)	0		0	0
Creatinine	Low	3 (18.8)	3 (18.8)		0	0
Creatinine	High	0	1 (6.3)		0	0
Glucose	Low	0	0		0	0
Glucose	High	0	1 (6.3)		0	0
SGOT	Low	0	0		0	0
SGOT	High	1 (6.7)	0		0	0
SGPT	Low	0	0		0	0
SGPT	High	0	0		0	0

SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamic pyruvic transaminase.

ISSN: 1475-2875