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Table 1 Intra-day assay precision and accuracy for LUME and 97–63 in rat plasma (n = 6)

From: Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97–78 in rat plasma using the HPLC–ESI-MS/MS method: application to drug interaction study

  LUME (ng/mL) 97-63 (ng/mL)
  3.9 10 100 400 3.9 10 100 400
Day 1         
Mean 3.9 9.6 97.4 387.3 4.1 10.2 104.0 405.2
SD 0.23 0.22 6.16 16.61 0.28 0.46 4.75 14.16
Precision (%)a 5.78 2.24 6.33 4.29 6.76 4.54 4.56 3.50
Accuracy (%)b 100.17 96.20 97.35 96.83 104.32 109.12 104.04 101.29
Day 2         
Mean 3.7 9.9 97.9 397.5 3.8 9.9 102.8 415.3
SD 0.27 0.55 6.93 11.74 0.23 0.53 3.99 9.35
Precision (%)a 7.14 5.51 7.07 2.95 6.01 5.27 3.88 2.25
Accuracy (%)b 95.90 99.47 97.92 99.38 99.40 106.52 102.78 103.83
Day 3         
Mean 3.8 9.5 103.0 415.0 3.8 10.3 104.3 386.5
SD 0.18 0.48 4.00 18.32 0.18 0.49 4.18 10.89
Precision (%)a 4.81 5.06 3.88 4.41 4.81 4.81 4.01 2.82
Accuracy (%)b 98.25 94.93 103.00 103.75 103.93 109.51 104.33 96.63
  1. a Expressed as % RSD = (SD/mean) × 100.
  2. b Calculated as (mean determined concentration/nominal concentration) × 100.