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Table 2 Inter-day assay precision and accuracy for LUME and 97–63 in rat plasma

From: Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97–78 in rat plasma using the HPLC–ESI-MS/MS method: application to drug interaction study

 

LUME (ng/mL)

97-63 (ng/mL)

 

3.9

10

100

400

3.9

10

100

400

Meana

3.8

9.7

98.1

399.9

4.0

10.2

103.7

402.3

SD

0.23

0.46

5.37

18.94

0.23

0.48

4.11

16.45

Precision (%)b

5.90

4.72

5.48

4.74

5.77

4.75

3.97

4.09

Accuracy (%)c

98.11

96.87

99.42

99.99

102.55

108.38

103.72

100.58

  1. a n = 18; three days with six replicates per day.
  2. b Expressed as % RSD = (SD/mean) × 100.
  3. c Calculated as (mean determined concentration/nominal concentration) × 100.