Parameters
|
Control
|
LUME with 97-78
|
---|
|
LUME (10 mg/kg)
|
97-78 (70 mg/kg)
|
LUME (10 mg/kg)
|
97-78 (70 mg/kg)
|
---|
AUC
0-t
(h*μg/mL)
|
16.52 ± 2.96
|
9.10 ± 1.48
|
10.64 ± 0.71*
|
8.04 ± 1.26
|
AUC
0-∞
(h*μg/mL)
|
17.42 ± 3.29
|
9.15 ± 1.46
|
11.02 ± 0.66*
|
8.15 ± 1.26
|
C
max
(μg/mL)
|
1.81 ± 0.75
|
1.35 ± 0.17
|
1.92 ± 0.62
|
1.79 ± 0.69
|
T
max
(h)
|
3.75 ± 1.50
|
2.2 ± 1.09
|
4 ± 2.45
|
0.5#
|
V
d
/F (L/kg)
|
39.45 ± 6.26
|
106.05 ± 30.57
|
62.73 ± 8.40*
|
142.03 ± 28.13
|
CL/F (L/h/kg)
|
0.59 ± 0.09
|
7.81 ± 1.26
|
0.91 ± 0.06 *
|
8.76 ± 1.38
|
t
1/2
(h)
|
46.94 ± 6.52
|
9.27 ± 1.33
|
47.82 ± 6.48
|
11.25 ± 1.45
|
RB%
|
--
|
--
|
64.41*
|
88.35
|
- All data are expressed as mean ± SD.
-
*P <0.05, vs LUME control; #P <0.05, vs 97–78 control.