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Table 4 The pharmacokinetic parameters of LUME and 97–78 in rats (n = 5 each)

From: Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97–78 in rat plasma using the HPLC–ESI-MS/MS method: application to drug interaction study

Parameters Control LUME with 97-78
  LUME (10 mg/kg) 97-78 (70 mg/kg) LUME (10 mg/kg) 97-78 (70 mg/kg)
AUC 0-t (h*μg/mL) 16.52 ± 2.96 9.10 ± 1.48 10.64 ± 0.71* 8.04 ± 1.26
AUC 0-∞ (h*μg/mL) 17.42 ± 3.29 9.15 ± 1.46 11.02 ± 0.66* 8.15 ± 1.26
C max (μg/mL) 1.81 ± 0.75 1.35 ± 0.17 1.92 ± 0.62 1.79 ± 0.69
T max (h) 3.75 ± 1.50 2.2 ± 1.09 4 ± 2.45 0.5#
V d /F (L/kg) 39.45 ± 6.26 106.05 ± 30.57 62.73 ± 8.40* 142.03 ± 28.13
CL/F (L/h/kg) 0.59 ± 0.09 7.81 ± 1.26 0.91 ± 0.06 * 8.76 ± 1.38
t 1/2 (h) 46.94 ± 6.52 9.27 ± 1.33 47.82 ± 6.48 11.25 ± 1.45
RB% -- -- 64.41* 88.35
  1. All data are expressed as mean ± SD.
  2. *P <0.05, vs LUME control; #P <0.05, vs 97–78 control.
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Malaria Journal

ISSN: 1475-2875

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