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Table 2 Association between nutrient supplementation and the rate of change in antibody levels

From: The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial

  Rate of change in antibody levels (Percentage antibody level change per gestation week, arbitrary units)
  LNS (n = 337) compared to IFA (n = 325) LNS (n = 337) compared to MMN (n = 347)
  Unadjusted Adjusted Adjusted p-value Unadjusted Adjusted Adjusted p-value
IgG to placental-binding isolate VSA −0.12 (−0.34, 0.11) −0.08 (−0.38, 0.22) 0.599 0.13 (−0.09, 0.36) 0.26 (−0.04, 0.55) 0.089
Opsonizing antibodies to placental-binding solate VSA −0.02 (−0.24, 0.19) −0.11 (−0.41, 0.19) 0.469 0.06 (−0.14, 0.27) 0.02 (−0.26, 0.30) 0.864
Opsonizing antibodies to non-placental-binding isolate VSA −0.002 (−0.12, 0.12) 0.01 (−0.16, 0.18) 0.888 −0.08 (−0.19, 0.03) 0.02 (−0.13, 0.18) 0.756
MSP-1 19kD −0.02 (−0.17, 0.12) 0.006 (−0.18, 0.19) 0.953 −0.06 (−0.19, 0.08) 0.04 (−0.14, 0.21) 0.693
MSP-2 −0.12 (−0.27, 0.03) −0.20 (−0.40, 0.02) 0.069 −0.15 (−0.32, 0.01) −0.25 (−0.46, −0.04)* 0.021*
MSP-3 −0.18 (−0.36, −0.01)* −0.21 (−0.44, 0.03) 0.080 −0.05 (−0.24, 0.14) −0.01 (−0.28, 0.27) 0.970
PfRh2 0.07 (−0.13, 0.27) 0.10 (−0.17, 0.37) 0.461 −0.21 (−0.40, −0.02)* −0.25 (−0.51, 0.02) 0.073
EBA-175 −0.06 (−0.18, 0.06) −0.04 (−0.20, 0.13) 0.639 −0.07 (−0.20, 0.05) −0.05 (−0.24, 0.14) 0.603
Schizont extract −0.03 (−0.28, 0.23) 0.13 (−0.21, 0.48) 0.450 0.003 (−0.26, 0.27) 0.10 (−0.26, 0.47) 0.583
  1. Results presented as regression coefficients (95% confidence interval) calculated by comparing the percentage rate of change in antibody levels in LNS group compared to IFA (reference group) and LNS group compared to MMN (reference group).
  2. The percentage rate of change in antibody levels from enrolment to 36 gw were adjusted for gravidity, maternal age, HIV, malaria infection at enrolment, malaria infection at 36 weeks, bed net use, body mass index at enrolment, socioeconomic status and location of residence.
  3. Statistical test: Multivariate linear regression analysis. Data reported as regression coefficient (95% confidence interval) and p-values. *Significant associations.