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Table 2 Association between nutrient supplementation and the rate of change in antibody levels

From: The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial

 

Rate of change in antibody levels (Percentage antibody level change per gestation week, arbitrary units)

 

LNS (n = 337) compared to IFA (n = 325)

LNS (n = 337) compared to MMN (n = 347)

 

Unadjusted

Adjusted

Adjusted p-value

Unadjusted

Adjusted

Adjusted p-value

IgG to placental-binding isolate VSA

−0.12 (−0.34, 0.11)

−0.08 (−0.38, 0.22)

0.599

0.13 (−0.09, 0.36)

0.26 (−0.04, 0.55)

0.089

Opsonizing antibodies to placental-binding solate VSA

−0.02 (−0.24, 0.19)

−0.11 (−0.41, 0.19)

0.469

0.06 (−0.14, 0.27)

0.02 (−0.26, 0.30)

0.864

Opsonizing antibodies to non-placental-binding isolate VSA

−0.002 (−0.12, 0.12)

0.01 (−0.16, 0.18)

0.888

−0.08 (−0.19, 0.03)

0.02 (−0.13, 0.18)

0.756

MSP-1 19kD

−0.02 (−0.17, 0.12)

0.006 (−0.18, 0.19)

0.953

−0.06 (−0.19, 0.08)

0.04 (−0.14, 0.21)

0.693

MSP-2

−0.12 (−0.27, 0.03)

−0.20 (−0.40, 0.02)

0.069

−0.15 (−0.32, 0.01)

−0.25 (−0.46, −0.04)*

0.021*

MSP-3

−0.18 (−0.36, −0.01)*

−0.21 (−0.44, 0.03)

0.080

−0.05 (−0.24, 0.14)

−0.01 (−0.28, 0.27)

0.970

PfRh2

0.07 (−0.13, 0.27)

0.10 (−0.17, 0.37)

0.461

−0.21 (−0.40, −0.02)*

−0.25 (−0.51, 0.02)

0.073

EBA-175

−0.06 (−0.18, 0.06)

−0.04 (−0.20, 0.13)

0.639

−0.07 (−0.20, 0.05)

−0.05 (−0.24, 0.14)

0.603

Schizont extract

−0.03 (−0.28, 0.23)

0.13 (−0.21, 0.48)

0.450

0.003 (−0.26, 0.27)

0.10 (−0.26, 0.47)

0.583

  1. Results presented as regression coefficients (95% confidence interval) calculated by comparing the percentage rate of change in antibody levels in LNS group compared to IFA (reference group) and LNS group compared to MMN (reference group).
  2. The percentage rate of change in antibody levels from enrolment to 36 gw were adjusted for gravidity, maternal age, HIV, malaria infection at enrolment, malaria infection at 36 weeks, bed net use, body mass index at enrolment, socioeconomic status and location of residence.
  3. Statistical test: Multivariate linear regression analysis. Data reported as regression coefficient (95% confidence interval) and p-values. *Significant associations.