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Fig. 1 | Malaria Journal

Fig. 1

From: Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination

Fig. 1

Evaluation of P. falciparum gametocyte production. Parasites (NF54 P. falciparum) were cultured in medium with 0.5 % AlbuMAX for both asexual and gametocyte cultures. a Box and whisker plots of gametocytaemia (% stage III-V gametocytes) obtained with the same optimized protocol across three independent sites (site 1 n = 6; site 2 n = 17; site 3 n = 14). b Kinetics of parasitaemia (asexual stages; dashed line) and gametocytaemia (gametocytes; solid line) during gametocytogenesis. The number of asexual forms increased up to maximum parasitaemia on days 2–6 (prior to NAG treatment). Sexual forms were first detected on day 2, with gametocytaemia reaching an average of 5 % on day 11. Data are from ≥4 independent biological experiments each performed in triplicate, ± SEM

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Malaria Journal

ISSN: 1475-2875

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