From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

Malaria Journal

Table 2 G6PD Activity

Effects on G6PD inhibition activity
G6PD activity in HEP-G2 (% of control, 182 ± 16 nmol/min/mg of protien)
	1 μM	50 μM	100 μM
DHEA	84 ± 7	39 ± 6	11 ± 2
RRx-001	78 ± 6	16 ± 4	6 ± 1

Cell-free extracts were incubated with each drug at concentrations of 1, 10 and 100 μM, and G6PD activities were measured. Dehydroepian drosterone (DHEA). Data represent the mean ± SD(n = 4)

ISSN: 1475-2875