|
Sex
| | | | |
|
Female
|
122 (49 %)
|
72 (48 %)
|
115 (53 %)
|
71 (53 %)
|
|
Age
|
24 (7–53)
|
10 (5–48)
|
24 (7–48)
|
8 (5–48)
|
|
Medical history (past 30 days)
| | | | |
|
Other malaria episode
|
18 (7 %)
|
7 (5 %)
|
16 (7 %)
|
16 (12 %)
|
|
Fever (N = 398)
|
90 (37 %)
|
78 (52 %)
|
59 (27 %)
|
76 (56 %)
|
|
Pretreatment with anti-malarial
|
31 (12 %)
|
20 (13 %)
|
20 (9 %)
|
20 (15 %)
|
|
Other treatment(s) received
|
113 (46 %)
|
75 (50 %)
|
98 (46 %)
|
83 (61 %)
|
|
Other major health problem(s)
|
6 (2 %)
|
3 (2 %)
|
0 (0 %)
|
4 (3 %)
|
|
Episode of convulsion (N = 394)
|
34 (14 %)
|
10 (7 %)
|
13 (6 %)
|
11 (8 %)
|
|
Known hypersensitivity to other drugs
|
0 (0 %)
|
5 (3 %)
|
2 (1 %)
|
5 (7 %)
|
|
Signs and symptoms on admission
| | | | |
|
Fever
|
220 (89 %)
|
129 (85 %)
|
197 (92 %)
|
121 (90 %)
|
|
Fever before enrolment (days and range)
|
3 (2–4)
|
3 (2–5)
|
3 (1–7)
|
3 (1–7)
|
|
Vomiting
|
100 (40 %)
|
78 (52 %)
|
113 (53 %)
|
78 (58 %)
|
|
Coma
|
23 (9 %)
|
12 (8 %)
|
5 (2 %)
|
11 (8 %)
|
|
Reported convulsions
|
72 (29 %)
|
19 (13 %)
|
59 (27 %)
|
14 (10 %)
|
|
Blantyre coma score (8–24 months)
|
3 (2–5)
|
−
|
4 (3–8)
|
−
|
|
Glasgow coma score (>2 years)
|
10.5 (5–13)
|
10 (8–15)
|
7.5 (4–5)
|
NA
|
|
Pallor
|
NA
|
NA
|
77 (36 %)
|
20 (15 %)
|
|
Jaundice
|
3 (1 %)
|
4 (3 %)
|
7 (3 %)
|
2 (1 %)
|
|
Shock
|
10 (4 %)
|
2 (1 %)
|
2 (1 %)
|
2 (1 %)
|
|
Respiratory distress
|
128 (52 %)
|
58 (38 %)
|
96 (45 %)
|
64 (47 %)
|
|
Severe anaemia (<5 g/dl) (N = 326 Q; 334 A)
|
8.1 (3 %) a
|
9.1 (2 %) a
|
15 (7 %) b
|
1 (1 %) b
|
|
Parasite count (per μl); geometric mean (95 % CI)
|
17 068 (12 119-24 038) c
|
12 022 (7 040-20 527) c
|
22 289 (15 498-32 057) c
|
12 346 (7 812-19 511) c
|
|
Prostration
|
204 (82 %)
|
122 (81 %)
|
171 (79 %)
|
120 (89 %)
|
|
Urine colouration (N = 391)
|
2 (1 %)
|
2 (1 %)
|
10 (5 %)
|
8 (6 %)
|
|
Clinical examination on admission
| | | | |
|
Weight (kg and SD)
|
11.1 (3.0)
|
33.2 (17)
|
11.2 (4)
|
27.6 (15)
|
|
Temperature (°C and SD) (N = 398)
|
38.1 (1)
|
38.3 (1)
|
38.1 (1)
|
38.4 (1)
|
|
Pulse
|
125 (70–180)
|
102 (64–148)
|
119 (60–171)
|
94 (60–140)
|
|
Respiratory rate per minute
|
42.5 (28–72)
|
39.0 (24–60)
|
40 (24–72)
|
40 (20–58)
|
|
Co-morbidity
|
82 (34 %)
|
51 (34 %)
|
80 (37 %)
|
58 (43 %)
|
