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Table 3 Relative antibody responses against P. falciparum antigens at delivery by treatment arm in Madang, PNG, adjusted for confounding and interaction variables

From: Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission

Variables

IgG schizont extract

IgG PfRh2

IgG MSP2

IgG MSP3

Opsonizing IgG E8B-ICAM

Opsonizing IgG CS2

Ā 

Coeff (95 % Cl)

p

Coeff (95 % Cl)

p

Coeff (95 % Cl)

p

Coeff (95 % Cl)

p

Coeff (95 % Cl)

p

Coeff (95 % Cl)

p

Intervention arma

āˆ’3.0 (āˆ’13.4, 7.4)

0.6

āˆ’3.6 (āˆ’10.9, 3.7)

0.3

āˆ’7.4 (āˆ’17.9, 3.1)

0.2

2.6 (āˆ’7.0, 12.2)

0.6

1.0 (āˆ’14.2, 16.2)

Ā 

āˆ’7.4 (āˆ’19.4, 4.5)

0.2

Gravidity

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

1

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

2

āˆ’2.0 (āˆ’8.3, 4.3)

0.5

āˆ’4.6 (āˆ’9.1, 0.2)

0.06

1.0 (āˆ’5.44, 7.42)

0.8

āˆ’0.7 (āˆ’6.6, 5.1)

0.8

50.3 (42.8, 57.9)

<0.0001

9.3 (2.5,16.1)

0.007

3

1.6 (āˆ’4.5, 7.6)

0.6

āˆ’0.5 (āˆ’4.8, 3.8)

0.8

1.9 (āˆ’4.3, 8.1)

0.6

5.72 (āˆ’0.04, 11.4)

0.06

32.8 (25.6, 40.1)

<0.0001

24.3 (17.9, 30.8)

<0.0001

Overall bed net use

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

No

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Intermittent

āˆ’1.8 (āˆ’6.0, 2.4)

0.4

āˆ’0.5 (āˆ’3.4, 2.5)

0.8

āˆ’1.6 (āˆ’5.9, 2.7)

0.5

0.3 (āˆ’5.6, 10.5)

0.9

1.2 (āˆ’3.8, 6.2)

0.6

āˆ’2.6 (āˆ’7.2, 1.9)

0.3

Regular

āˆ’13.0 (āˆ’45.2, 19.2)

0.4

āˆ’5.3 (āˆ’28.1, 17.6)

0.7

āˆ’12.0 (āˆ’45.0, 20.9)

0.5

āˆ’2.5 (āˆ’32.7, 27.6)

0.9

25.4 (āˆ’13.1, 63.9)

0.2

āˆ’10.6 (āˆ’45.0, 23.8)

0.6

Residence

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Urban

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Peri-urban

0.3 (āˆ’8.4, 8.8)

0.9

āˆ’1.3 (āˆ’7.1, 5.9)

0.7

1.5 (āˆ’7.2, 10.2)

0.7

2.0 (āˆ’5.9, 10.0)

0.6

2.2 (āˆ’10.4, 14.9)

0.4

āˆ’1.9 (āˆ’11.8, 7.9)

0.7

Rural

8.6 (1.2, 15.9)

0.02

5.0 (āˆ’0.2, 10.0)

0.06

8.5 (1.2, 16.0)

0.02

8.5 (1.7, 15.2)

0.01

āˆ’4.1 (āˆ’14.8, 6.6)

0.7

āˆ’0.4 (āˆ’8.8, 8.0)

0.9

Migrant

13.0 (āˆ’1.3, 27.3)

0.07

āˆ’0.1 (āˆ’10.1, 10.0)

0.9

13.3 (āˆ’1.1, 27.7)

0.07

āˆ’1.1 (āˆ’14.3, 12.1)

0.9

6.4 (āˆ’14.4, 27.3)

0.5

2.7 (āˆ’13.7, 19.1)

0.8

Ethnicity

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Madang/Morobe

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Sepik

āˆ’4.7 (āˆ’11.0, 11.0)

0.2

0.3 (āˆ’4.7, 5.2)

0.9

āˆ’5.4 (āˆ’12.6, 1.7)

0.1

1.7 (āˆ’4.8, 8.2)

0.6

āˆ’1.6 (āˆ’11.9, 8.7)

0.8

4.7 (āˆ’12.8, 3.4)

0.2

Highlands

āˆ’12.3 (āˆ’21.9, āˆ’2.6)

0.01

āˆ’0.5 (āˆ’7.2, 6.2)

0.9

āˆ’10.9 (āˆ’20.6, āˆ’1.2)

0.03

āˆ’1.0 (āˆ’9.9, 7.7)

0.82

āˆ’3.7 (āˆ’17.7, 10.4)

0.8

āˆ’6.4 (āˆ’17.4, 4.7)

0.4

Others

āˆ’4.4 (āˆ’13.9, 5.2)

0.4

āˆ’2.5 (āˆ’9.3, 4.2)

0.5

āˆ’7.5 (āˆ’17.0, 2.2)

0.1

1.3 (āˆ’7.5, 10.1)

0.8

āˆ’2.4 (āˆ’16.5, 11.7)

0.9

āˆ’2.6 (13.5, 8.3)

0.6

SP-AZ-graviditya

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

1

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

2

āˆ’5.6 (āˆ’14.77, 3.56)

0.2

7.1 (0.57, āˆ’13.56)

0.1

āˆ’6.5 (āˆ’15.90, 2.87)

0.2

āˆ’3.5 (āˆ’12.10, 5.06)

0.4

āˆ’6.5 (āˆ’17.48, 4.50)

0.3

āˆ’0.3 (āˆ’10.1, 9.5)

1.0

3

āˆ’5.5 (āˆ’14.3, 5.6)

0.3

1.2 (āˆ’5.1, 7.5)

0.7

āˆ’7.6 (āˆ’16.7, 1.5)

0.1

āˆ’7.5 (āˆ’15.8, 0.8)

0.08

āˆ’5.6 (āˆ’16.2, 5.0)

0.3

0.01 (āˆ’9.5, 9.5)

1.0

SP-AZ-residencea

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Urban

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Peri-urban

5.0 (āˆ’7.7, 17.6)

0.4

2.1 (āˆ’6.7, 11.0)

0.6

2.9 (āˆ’9.9, 15.7)

0.7

āˆ’1.1 (āˆ’12.8, 10.6)

0.9

āˆ’8.2 (āˆ’26.8, 10.3)

0.4

8.4 (āˆ’6.1, 23.0)

0.3

Rural

2.7 (āˆ’8.2, 13.6)

0.6

2.7 (āˆ’5.0, 10.3)

0.5

7.5 (āˆ’3.5, 18.5)

0.2

āˆ’3.9 (āˆ’14.0, 6.1)

0.4

āˆ’2.8 (āˆ’18.7, 13.1)

0.7

7.7 (āˆ’4.8, 2.2)

0.2

Migrant

1.2 (āˆ’19.5, 21.9)

0.9

7.2 (āˆ’7.3, 21.7)

0.3

āˆ’5.63 (āˆ’26.55, 15.29)

0.6

3.7 (āˆ’15.43, 22.78)

0.7

āˆ’17.6 (āˆ’47.8, 12.6)

0.3

0.5 (āˆ’23.3, 24.2)

1.0

SP-AZ-ethnicitya

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Madang/Morobe

Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 

Sepik

0.02 (āˆ’11.0, 11.00)

1.0

1.9 (āˆ’5.9, 9.6)

0.6

5.1 (āˆ’6.0, 16.2)

0.4

āˆ’4.6 (āˆ’14.7, 5.6)

0.4

āˆ’1.6 (āˆ’17.7, 14.4)

0.8

11.5 (āˆ’1.1, 24.1)

0.07

Highlands

āˆ’1.0 (āˆ’16.0, 14.0)

0.9

āˆ’1.3 (āˆ’11.8, 9.2)

0.8

1.6 (āˆ’13.6, 16.7)

0.8

āˆ’5.53 (āˆ’19.4, 8.3)

0.4

āˆ’2.8 (āˆ’24.7, 19.1)

0.8

6.7 (āˆ’10.6, 23.9)

0.5

Others

0.5 (āˆ’14.2, 13.1)

0.9

3.3 (āˆ’6.3, 12.9)

0.5

6.6 (āˆ’7.2, 20.5)

0.4

āˆ’3.6 (āˆ’16.2, 9.0)

0.6

āˆ’1.0 (āˆ’21.1, 19.2)

0.9

āˆ’3.6 (āˆ’19.3, 12.1)

0.7

  1. Data represented as coefficients and 95Ā % confidence interval (Multiple linear regression models), P-values are also shown
  2. SP sulfadoxine-pyrimethamine, AZ azithromycin, against control group (SP-CQ), CQ chloroquine
  3. aRefers to relative antibody responses in intervention group (SP-AZ). A positive coefficient implies an increase of antibody levels. A negative coefficient implies a decrease of antibody levels. Significant associations (pā€‰<ā€‰0.05) highlighted in bold